Parambikulam Tiger Reserve is situated in the Chittur taluk of Palakkad revenue district in the state of Kerala. Surrounding the sanctuary are Pollachi and Valparai taluks of Coimbatore district in the state of Tamil Nadu, and Thrissur and Mukundapuram taluks of Thrissur district of Kerala.
The sanctuary is approachable only by road and is 80 km from both Palakkad (Kerala state) and Coimbatore (Tamil Nadu state).
The nearest town is Pollachi , which is 41 km away. There is no road directly connecting Parambikulam with the rest of Kerala state, and all visitors must pass through Pollachi in Tamilnadu state.